Jesse Goodman, 2017, Computer Science

Protein-loaded microspheres have recently gained influence through promising applications such as drug delivery and tissue engineering. However, it has always been challenging to control the release rate of the loaded protein(s). This summer, I worked to understand how certain fabrication parameters affect the release profiles of these microspheres. My project focused on monitoring the release of horseradish peroxidase (HRP) from PLGA microspheres manufactured via the double emulsion solvent evaporation method. After tweaking certain parameters in the fabrication process, I could then monitor how these changes affected the release of HRP over a 24-hour time period. Through collaboration with another research group in the Operations Research and Financial Engineering (ORFE) department, mathematical models describing the parameters versus protein release relationship were developed and used to target specific protein release profiles. Such optimization techniques were necessary, as each release profile experiment proved to be tedious and time-consuming. While this internship did not alter my choice of concentration, computer science, it did provide me with the invaluable experience of playing a major role in a professional research project.