Zehao Wu ’26

Major

Ecology and Evolutionary Biology

Project Title

Naturalizing the Environmental Experience of “Model Mammals” for Immunology and Beyond

Certificate(s): East Asian Studies, Environmental Studies

In many biomedical experiments, lab mice are considered “model mammals.” However, immune profile differences contribute to a disparity between mice and clinical results. At Stony Ford Research Station, I participated in a study of how releasing lab mice into a natural environment impacts how their immune system responds to parasitic nematode (Trichuris muris) infection. In the field, I assisted with cleaning the mouse feeders, refilling food and water and fecal sampling. I also edited camera footage of mouse activity to present to the lab and assisted with compiling daily reports that checked the number of mice and the number of escapees. I found that observing mice’s behavior patterns and social interactions was one of the most captivating aspects of the work. Through this experience, I gained a more robust knowledge of fieldwork logistics and a more advanced understanding of R programming. This internship affirmed my interest in the intersection of environmental science and immunology. Although fieldwork was initially challenging, I plan to continue researching immunology and environmental science through lab or fieldwork.



Internship Year

2023

Project Category

Biodiversity and Conservation

Organization(s)

The Graham Group, Department of Ecology and Evolutionary Biology, Princeton University - Princeton, New Jersey

Mentor(s)

Andrea Graham, Professor of Ecology and Evolutionary Biology; Yoon Chang, Ph.D. candidate, Ecology and Evolutionary Biology; David Chang van Oordt, Postdoctoral Research Associate, Ecology and Evolutionary Biology; Alec Downie, Ph.D. candidate, Ecology and Evolutionary Biology